CBS Local — Scientists at Northwestern University have released new findings that point to a possible breakthrough in diabetes and anti-aging research. Ironically, the futuristic medical treatment may be carried by people who choose to live in America’s past: the Amish.

According to the study, published in Science Advances, a genetic mutation found in a single Amish community in rural Indiana may protect against Type 2 diabetes and age-related disorders like heart disease or dementia.

The mutation affects a protein called plasminogen activator inhibitor-1 (PAI-1) that is closely associated with blood clotting. The Amish residents with the mutation, around five percent of the community, were found to have nearly half the amount of PAI-1 in their bodies. Researchers also wrote that carriers of the mutation, which was first discovered in 1991, lived 10 years longer than other Amish and had never been diagnosed with Type 2 diabetes.

“This is a rare genetic mutation that appears to protect against biological ageing in humans,” Northwestern’s Douglas Vaughan said, via The Guardian. “It seems that there’s a sweet spot. You don’t want too much PAI-1, and you don’t want zero.”

Professor Vaughan added that some of the Amish who were found to have no PAI-1 at all suffered from bleeding disorders, as the body lost its ability to clot properly. Scientists are now conducting trials of new medication that targets PAI-1 in hopes it will improve current diabetes treatments.

“We are very optimistic about its potential role not just in slowing aging but in reducing age-related morbidities,” Vaughan said.

  1. Great blog I also have written an in-depth article about ageing and what you can try to slow the process at

Leave a Reply to Rino Ingenito Cancel reply

Please log in using one of these methods to post your comment:

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

More From CBS Tampa

Gov. Rick Scott Announces Senate RunFlorida Gov. Rick Scott formally announced his run for the U.S. Senate seat held by Democrat Bill Nelson.
Topless Protester Charges Bill CosbyA topless protester with "Women's Lives Matter" written on her body jumped a barricade and got within a few feet of Bill Cosby on Monday.
Best Party Beaches Around Tampa BayIt's illegal to drink alcohol on most of Tampa Bay's beaches - unless you know about these next six locations.

Listen Live