That comes Monday night when No. 2-seeded Simona Halep takes on former No. 1 and five-time major champion Maria Sharapova, who was given a wild-card entry to the U.S. Open after returning from a 15-month doping ban. Halep is winless against Sharapova in six previous meetings.
Play begins in the day session in Arthur Ashe Stadium with Wimbledon champ Garbine Muguruza against American Varvara Lepchenko. The 2014 U.S. Open champion Marin Cilic is next up against aptly named Tennys Sandrgen of the U.S. And seven-time major champion Venus Williams plays Viktoria Kuzmova of Slovakia.
Other big names on Monday’s schedule include No. 4 Alexander Zverev, two-time Wimbledon champion Petra Kvitova and top American John Isner.